GBS (Group B Streptococcus)
Groub B Streptococcus (GBS, Streptococcus agalactiae) is the leading cause of life-threatening infections in newborns. Rapid and sensitive detection of neonatal infections and initiation of appropriate treatment is needed to minimize morbidity and mortality among newborns. PCR has proved to be a useful diagnostic tool due to its increased sensitivity and specificity and fast results.
For prenatal screening, the accuracy and timing of testing is important to prevent unnecessary use of intra-partum antibiotic prophylaxis (IAP).
The GenomEra® GBS assay simplifies and speeds up GBS testing by providing reliable results from enriched broth samples in less than one hour. The assay is suitable for both over-night and quick 4 h cultured broth enrichment samples and also for positive blood cultures.
Over-night enrichment broth samples
Sensitivity: 97/99 = 98.0%
Specificity: 288/293 = 98.3%
Short 4 h enrichment broth samples
Sensitivity: 27/28= 96.4%
Specificity: 83/86 = 96.5%
Assay steps for broth cultures:
Dispense suspension into tube and vortex.
Pipette 35 ul to the test chip.
Start the GenomEra CDX assay run.